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In the absence of amphetamine, VMAT2 will normally move monoamines (e.g., dopamine, histamine, serotonin, norepinephrine, etc.) from the intracellular fluid of a monoamine neuron into its synaptic vesicles, which store neurotransmitters for later release (via exocytosis) into the synaptic clef


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Although low levels of these vitamins and minerals do not lead to ADHD, if there is a deficiency in one or more vitamins or minerals, adding a supplement in combination with other treatments may be helpful—not as a substitute. However, some individuals with ADHD may have low levels of vitamins and minerals, such as vitamin D, B6, iron, magnesium, and zinc. What’s more, Adderall is just one part of a treatment plan that may include cognitive-behavioral therapy as well as work or educational interventions. Patients will also be closely monitored during treatment with Adderall. These severe side effects may include high blood pressure and heart rate, stroke, heart attack, and sudden death, among others.
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The Cochrane reviews[note 3] on the treatment of ADHD in children, adolescents, and adults with pharmaceutical amphetamines stated that short-term studies have demonstrated that these drugs decrease the severity of symptoms, but they have higher discontinuation rates than non-stimulant medications due to their adverse side effect


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